Daniel Böttger got an amygdalectomy as part of a craniotomy to remove his astrocytoma, and thinks that many people would benefit from amygdalectomy because their lives are ruled by fear and anxiety. #medicine
on 02026-09-11“The 500-dalton rule for the skin penetration of chemical compounds” by Bos and Menardi in 02000, describing conditions when this does or doesn’t hold. #paper #PDF #medicine #toread
on 02026-08-19Neuroleptic #drugs can make your eyes roll uncontrollably in a scary way that isn’t dangerous. #medicine
on 02026-08-19#medicine #paper about a patient whose #smoking of #Datura cigarettes masked his chronic obstructive pulmonary disease (COPD) until quite late
on 02026-07-17#history of #Datura stramonium cigarettes (with tobacco) as #medicine for asthma and for #smoking cessation; “chamico” in Argentine Spanish, from Quichua “chamiku”.
on 02026-07-17#paper evaluating 2% and 6% #catnip-oil (>92% nepetalactone) as an insect repellent. #medicine #toread
on 02026-07-16#paper evaluating #catnip-oil (>95% nepetalactone) as an insect repellent. #medicine #toread
on 02026-07-166% #catnip-oil lotion was as effective as 15% deet insect repellent at repelling mosquitoes in Uganda. #medicine
on 02026-07-16“In this post hoc analysis of a randomized clinical trial including 498 children, high-dose vitamin D₃ supplementation was associated with better verbal and visual memory and set shift at age 10 years compared with standard-dose vitamin D₃, although the association with flexibility or set shift did not remain significant after false discovery rate correction.” #medicine #paper #toread
on 02026-06-07#Burntsushi is recovering from “anti-NMDA receptor encephalitis”, “an autoimmune disorder where your body’s normally helpful antibodies start acting strangely,” which “leads to inflammation in the brain.” #medicine
on 02026-06-03apparently #SARMs are the hot new thing in #bodybuilding because they have anabolic effects with less side effects than older #steroids. Also not all of them are steroidal. #drugs #medicine #life-extension
on 02026-05-27why the Hippocratic oath prohibited lithotomy of kidney stones. #medicine #history
on 02026-05-04“The antioxidant N-acetylcysteine protects from lung emphysema but induces lung adenocarcinoma in mice” #NAC #toxicology #medicine #cancer #paper
on 02026-04-22WHO "essential medicine" N-acetylcysteine ("NAC") is the standard treatment for #paracetamol overdose; it replenishes depleted glutathione reserves, which conjugate N-acetyl-p-benzoquinone imine (“NAPQI”), the toxic metabolite. It’s also a mucolytic, decreases the effects of alcohol, and sometimes helps with mental disorders. #drugs #toxicology #medicine
on 02026-04-22#FDA proposed rule from 02002 on #ibuprofen and other #NSAIDs to improve their labeling. Highly recommended by Dynomight. #drugs #medicine
on 02026-04-22#paracetamol is safer than #ibuprofen, but perverse incentives make it hard to find that out. #Dynomight #drugs #NSAIDs #medicine
on 02026-04-22claims that #myopia is due to not spending enough time outdoors. #medicine
on 02026-02-16apparently in #medicine they used to use ferric chloride to treat poison ivy (dermatitis venenata) but it can permanently color the skin. #safety
on 02026-01-14#paper on a guy whose stomach they had to remove at the Hospital Posadas because he tried to commit #suicide by drinking 500 mℓ of ferric chloride solution, which caustically etched his mouth, stained his teeth brown, and produced metabolic acidosis. They treated his acute iron intoxication with chelation therapy. Finally he died in the hospital 8 days after the operation, “product of a systemic inflammatory response syndrome (SIRS) due to respiratory complications in intensive care unit.” #medicine #materials #safety #toxicology
on 02026-01-14#medicine #video with #Mikhail-Varshavski that surprisingly isn’t vapid at all, about extreme medical cases he’d seen. Still just talking head and stock footage filler though. This video would have been better as a blog post.
on 02026-01-06#medicine #humor #video of being a paramedic
on 02026-01-06Vishal Prasad thinks everyone should eat 5 grams of creatine per day, dry. I don’t even know what to tag this. #medicine? #health? #supplements?
on 02025-12-12HMB is a dietary supplement people take to gain muscle and/or concentrate better. #medicine
on 02025-12-02#news: dropping #GLP-1 agonists like #Ozempic (though this trial was tirzepatide, aka Zepbound) results in 82% of cases of regaining more than 25% of the lost weight, in 57% of cases of regaining more than 50%, and 24% of cases of regaining more than 75%, with corresponding worsening or not of other metabolically-induced problems. #medicine
on 02025-11-26#history of #cancer #medicine: tyrosine kinase inhibitors were the first kinase inhibitors approved
on 02025-11-05“Receptor tyrosine-protein kinase erbB-2” is “frequently referred to as HER2 (human epidermal growth factor receptor 2) or CD340 (cluster of differentiation 340).” #cancer #medicine
on 02025-11-05ethics in #medicine and #human-experimentation
on 02025-11-05#history of #ribociclib getting approved in the #UK in only July of this year. #medicine #politics #cancer #ciclibs
on 02025-11-05#medicine #USA #politics #Medicare lawsuit for Eylea
on 02025-11-05#OECD #statistics on #infant-mortality. Argentina is 8.2 deaths per 1000 live births, Turkey is 9.8, Mexico is 13.4, Chile is 6.5, USA and Slovakia are 5.6 #medicine
on 02025-11-05“Recent progress of CDK4/6 inhibitors’ current practice in breast #cancer” from 02024. #ciclibs #medicine
on 02025-11-05“The Difference in Prognostic Outcomes Between De Novo Stage IV and Recurrent Metastatic Patients with Hormone Receptor-positive, HER2-negative Breast #Cancer” from 02018 just after ribociclib was approved #ciclibs #medicine
on 02025-11-05Most treatments in #medicine are less effective than parachutes. “Among medical therapies, that [an NNT that comes very close to 1] is an unheard of benefit. In fact, in a study of over 80,000 reviews in the Cochrane database, there was only 1 therapy that reliably had a reduction in [mortality] as large as 33%! (Pereira 2012) Empirically speaking, we just don’t have parachutes in modern medicine.”
on 02025-10-21#PDF #ebook of "The Epidemics of the Middle Ages", by J.F.C. Hecker, translated by B.G. Babington, published by the Sydenham Society #history #medicine
on 02025-10-02#paper “Review: Lessons Learned From Clinical Trials Using Antimicrobial Peptides (AMPs)” #drugs #medicine #history #magainin
on 02025-09-28#paper on the #history of #infliximab, “first such therapeutic mAb, an anti-TNF-α”. #drugs #medicine
on 02025-09-28"Infliximab" was approved in the #USA in 01998. #history #drugs #medicine
on 02025-09-28More #medicine #humor #video with #Mikhail-Varshavski but this time not totally vapid
on 02025-09-25#medicine #humor #video with ice cubes in the rectum, etc.
on 02025-09-25“People who are very early stage demented also tend to wake up more confused post op. In the older population, it is very well documented that a general anesthetic can lead to some cognitive decline for months after surgery. But whether that is all #anesthesia or in conjunction with their severe disease process that lead to surgery causing a decline, its hard to say.” Oh my. #medicine
on 02025-09-1602019 #medicine review #CC BY #paper about #asbestos and lung #cancer. “The new knowledge gained through this review provides the evidence for synergism between asbestos exposure and tobacco smoke in lung cancer causation at a biological level. The evaluated statistical data conform best to a multiplicative model for the interaction effects of asbestos and smoking on the lung cancer risk, with no requirement for asbestosis. Any asbestos exposure, even in a heavy smoker, contributes to causation. Based on this information, we propose criteria for the attribution of lung cancer to asbestos in smokers and non-smokers.”
on 02025-09-02#medicine #paper about a guy who survived accidentally drinking 250mℓ of 35% H₂O₂. Apparently 3.5ℓ of oxygen evolves from 30mℓ of 35% H₂O₂, so you can get gas injury.
on 02025-04-12famous #paper on evidence-based #medicine #research: “Parachute use to prevent death and major trauma related to gravitational challenge: systematic review of randomised controlled trials”
on 02024-06-23list of psychiatric #drugs from CrazyMeds, including mostly antidepressants and antipsychotics. #medicine
on 02024-01-13in a meta-analysis of 11 RCTs, using artificial sweeteners did reduce body weight, but only slightly: “Overall, the NAS [non-calorie artificial sweetener] group showed significantly reduced body weight -1.07 kg (95% confidence interval (CI) 0.41 to 1.72). Subgroup analyses in children (aged < 18 years) revealed that the NAS group showed significantly reduced body weight 1.18 kg (95% CI 0.44 to 1.93). However, adults did not have association between NAS and weight. Subgroup analysis of duration showed for the short term that the NAS group had significantly reduced body weight 0.69 kg (95% CI 0.34 to 1.04); and even in long term, the NAS group had significantly reduced body weight 1.32 kg (95% CI 0.32 to 2.31).” #health-care #science #research #medicine #food-additives
on 02023-10-08#paper on #diarrhea finds that regular #poop is 72–76% water, while “runny” diarrhea is 91.2% water. “Semiliquid” diarrhea is 88.5% water without #steatorrhea or 81.5% with. Steatorrhea solids were typically ⅓ to ½ fat. “Semi-formed stools from patients with steatorrhea had a lower water content than did formed stools from normal people.” “Bacterial mass represents 30%–75% of total stool weight in normal people.” #health #medicine
on 02023-09-04a guy is allergic to his own orgasms, with flu-like symptoms: coughing, sneezing, runny nose, for 2–7 days. "Post-orgasmic illness syndrome" ("POIS"). #health #medicine
on 02022-12-302% #carboxymethylcellulose ingestion induces Crohn’s-disease-like symptoms in genetically susceptible mice, including bacterial overgrowth and inflammation. “CMC is an ideal suspect to account for the rise of #IBD in the 20th century.” #food-additives #health #medicine
on 02022-09-29discussion of a #vitamin-D overdose article. Physician Deva Boone who wrote it: “Vitamin D supplements can be very helpful for those with a deficiency. The point that I am trying to make is that Vitamin D should not be thought of as a dietary supplement. I am seeing more and more people with high calcium levels from being on high-dose Vitamin D. If you treat Vitamin D like the steroid hormone that it is, you will treat it like a medicine, and not take outrageous doses because someone online suggested it.” #medicine #health
on 02020-11-18“#Modafinil protects hippocampal neurons by suppressing excessive autophagy and apoptosis in mice with sleep deprivation” #medicine #paper #health
on 02020-11-18How much #Vitamin-D is too much? #medicine #paper
on 02020-11-12“#Vitamin-D Supplementation Improves Cognitive Function Through Reducing Oxidative Stress Regulated by Telomere Length in Older Adults with Mild Cognitive Impairment: A 12-Month Randomized Controlled Trial” #medicine #paper only 800 IU/day!
on 02020-11-12Billions of titanium dioxide nanocrystals (#TiO2) in pancreas tissue are associated with type-2 #diabetes, being found in all 8 diabetic samples and ZERO of three non-diabetic samples. #health-care #science #research #medicine #food-additives
on 02018-06-21#LASIK #surgery can create nighttime glare and double vision and stuff. “half of all people who had healthy eyes before Lasik developed visual aberrations for the first time after the procedure” but usually subside within months. #health-care #medicine
on 02018-06-12#paper purporting to report that THC from #marijuana reverses #dementia in mice. “Here we show that a low dose of Δ⁹-tetrahydrocannabinol (THC) reversed the age-related decline in cognitive performance of mice aged 12 and 18 months. This behavioral effect was accompanied by enhanced expression of synaptic marker proteins and increased hippocampal spine density. THC treatment restored hippocampal gene transcription patterns such that the expression profiles of THC-treated mice aged 12 months closely resembled those of THC-free animals aged 2 months.” #medicine
on 02017-06-18on NSAID #drugs and how they tried to avoid the stigma of the iatrogenic catastrophe of "steroid wrecks". #medicine #history #paper
on 02017-06-14#PDF of “Origins and Evolution of Antibiotic Resistance” #medicine #paper #public-health
on 02017-05-19brief (7100 word) review of Guyenet’s book on #nutrition science and #obesity #medicine
on 02017-05-19The 2002 #paper that found that arthroscopic surgery did not help osteoarthritis of the knee. #medicine
on 02017-05-11a time-motion study #paper on cataract #medicine from #India, published in 2008 in the Indian Journal of Public Health
on 02017-05-022011 #medicine #paper on a randomized clinical trial of calcium supplements in “community dwelling postmenopausal women”. Found supplementation increased the risk of myocardial infarction and of stroke, though the 95% confidence intervals barely exclude the null hypothesis.
on 02017-04-30“Effect of calcium supplements on risk of myocardial infarction and cardiovascular events: meta-analysis”, 2010 #medicine #paper showing that calcium supplements are dangerous; 95% confidence interval for the hazard ratio of myocardial infarctions was 1.02 to 1.67
on 02017-04-30“Vascular events in healthy older women receiving calcium supplementation: randomised controlled trial” calcium supplements cause strokes #medicine #paper
on 02017-04-15“Should We Prescribe Calcium Supplements For Osteoporosis Prevention?” 2014 #medicine #paper saying that calcium supplements are mostly actively harmful
on 02017-04-15“Thrombosis remains a significant and potentially catastrophic complication of #polyethylene-terephthalate (Dacron) prosthetic vascular graft implantation.” Not clear whether boiling it in lye actually helped. #materials #science #medicine #paper
on 02016-06-28#drugs #science #medicine #health-care
on 02015-12-16about #inflammation in #medicine
on 02015-12-16overview #paper, “meal frequency and timing in #health and disease”, related to humans and circadian rhythms, including things like intermittent #fasting and #ketogenic diets. #medicine
on 02015-12-04losing a gram of fat from your pancreas through caloric restriction can eliminate type 2 #diabetes? This seems dubious to me; don’t type-2 diabetics have high insulin levels that their non-pancreas cells are just insensitive to? #medicine
on 02015-12-03Cecropia pachystachya (#ambay) is an anti-inflammatory and maybe antioxidant. No word on toxicity. #herbal #medicine #paper
on 02015-11-22#pdf #paper on anti-leishmaniasis activity of #ambay (Cecropia pachystachya). #herbal #medicine
on 02015-11-22#abstract says Cecropia pachystachya (#ambay) is effective against P. falciparum malaria in mice; the active ingredient is tormentic acid; roots have the best therapeutic index (i.e. lowest toxicity at active dose). #herbal #medicine
on 02015-11-22#Abstract says Cecropia pachystachya (#ambay) extract lowers blood pressure (#hypotension) in rats at 90–300 mg/kg and caused death by respiratory paralysis at 320 mg/kg (3g dry leaves/kg), which is almost an order of magnitude higher than the “ethnotherapeutic” dose. #herbal #medicine #toxicology
on 02015-11-22Cecropia pachystachya (#ambay) was administered orally at 0.76 g/kg to mice; caused kidney enlargement but no behavioral or therapeutic effects. #herbal #medicine #toxicology
on 02015-11-22Cecropia glazioui (related to #ambay) toxicity is low. #herbal #medicine #toxicology
on 02015-11-22#Ambay, commonly used in #herbal #medicine and also known as Cecropia adenopus and Cecropia pachystachya, lowers blood pressure in vivo in rats, but toxicity is low — no lethality was shown with up to four to six times the effective dose of 100 mg/kg of methanol (!) extract. #toxicology
on 02015-11-22human #urine can substantially vary from acidic (pH 4.5) to alkaline (pH 8) #medicine #paper
on 02015-11-03