> In 1787 painter and biographer Albert Christoph Dies swallowed, by accident, approximately 3⁄4 ounce (20 g) of lead acetate. His recovery from this poison was slow and incomplete. He lived with illnesses until his death in 1822.[18][19]
on 02026-08-14#formaldehyde in air is positively correlated with eye and nasal irritation down to 46 ppb. #toxicology #pollution
on 02026-06-16“The antioxidant N-acetylcysteine protects from lung emphysema but induces lung adenocarcinoma in mice” #NAC #toxicology #medicine #cancer #paper
on 02026-04-22WHO "essential medicine" N-acetylcysteine ("NAC") is the standard treatment for #paracetamol overdose; it replenishes depleted glutathione reserves, which conjugate N-acetyl-p-benzoquinone imine (“NAPQI”), the toxic metabolite. It’s also a mucolytic, decreases the effects of alcohol, and sometimes helps with mental disorders. #drugs #toxicology #medicine
on 02026-04-22#paper on a guy whose stomach they had to remove at the Hospital Posadas because he tried to commit #suicide by drinking 500 mℓ of ferric chloride solution, which caustically etched his mouth, stained his teeth brown, and produced metabolic acidosis. They treated his acute iron intoxication with chelation therapy. Finally he died in the hospital 8 days after the operation, “product of a systemic inflammatory response syndrome (SIRS) due to respiratory complications in intensive care unit.” #medicine #materials #safety #toxicology
on 02026-01-14#toxicology #maps of Silicon Valley, with all the Superfund sites marked
on 02025-12-12“While MPTP itself has no psychoactive effects, the compound may be accidentally produced during the manufacture of MPPP, a synthetic opioid drug with effects similar to those of morphine and pethidine (meperidine). The Parkinson-inducing effects of MPTP were first discovered following accidental injection as a result of contaminated MPPP.” #toxicology #oops
on 02024-12-29#paper on pennyroyal #toxicology profiling four cases of fatal ingestion and a number of less serious ones, with metabolite levels measured in two cases
on 02024-12-13#EU #PDF on #borates #toxicology from 02008
on 02023-02-08#PDF on #borates #toxicology from 02021: “All borates covered in this RMOA have a harmonised classification as toxic to reproduction for both developmental and fertility effects, i.e. Repr. 1B (H360FD) according to Annex VI of Regulation (EC) No 1272/2008 (CLP). Due to Repr. 1B classification, Entry 30 of Annex XVII to REACH applies to borates covered in this RMOA. ... placing on the market or use of substances as such, as constituents of other substances or in mixtures at concentrations of more than 0.3% (w/w) for supply to the general public will be prohibited (with the exemption of medical devices such as contact lens fluids which, hence, need to be assessed under the Medical Device Regulation)” #EU #politics
on 02023-02-08#borates #toxicology: LD₅₀ 2660 mg/kg, “a review of 784 human poisonings with boric acid (10–88 g) reported no fatalities, with 88% of cases being asymptomatic. ... Although it does not appear to be carcinogenic, studies in dogs have reported testicular atrophy after exposure to 32 mg/kg bw/day for 90 days. This level, were it applicable to humans at like dose, would equate to a cumulative dose of 202g over 90 days for a 70 kg adult, not far lower than the above LD₅₀. ... Following the registration and review completed as part of REACH, the classification of Boric Acid CAS 10043-35-3 / 11113-50-1 is listed from 1 December 2010 is H360FD (May damage fertility. May damage the unborn child.)” This is nonsense. #EU #politics
on 02023-02-08#lead poisoning from bullets; Colin Goddard has dozens of bullet fragments from the Virginia Tech shooting and had blood levels “seven times higher than what is considered safe” which turns out to be 37 μg/dl, so he’s on chelation therapy. “at least 457 adult shooting survivors tested positive for elevated blood lead levels from retained bullet fragments between 2003 and 2012” #toxicology
on 02021-09-06it’s possible to get #lead poisoning from bullets embedded in your body. #toxicology
on 02021-09-06A “wellness” livestreamer #quack in #China poisoned herself by biting an agave leaf, mistaking it for aloe vera, but suffered no worse than sores in her mouth and throat. #toxicology
on 02017-07-11#PDF on #toxicology of DEET insect repellent
on 02017-05-05#toxicology of cassava
on 02015-12-07#Abstract says Cecropia pachystachya (#ambay) extract lowers blood pressure (#hypotension) in rats at 90–300 mg/kg and caused death by respiratory paralysis at 320 mg/kg (3g dry leaves/kg), which is almost an order of magnitude higher than the “ethnotherapeutic” dose. #herbal #medicine #toxicology
on 02015-11-22Cecropia pachystachya (#ambay) was administered orally at 0.76 g/kg to mice; caused kidney enlargement but no behavioral or therapeutic effects. #herbal #medicine #toxicology
on 02015-11-22Cecropia glazioui (related to #ambay) toxicity is low. #herbal #medicine #toxicology
on 02015-11-22#Ambay, commonly used in #herbal #medicine and also known as Cecropia adenopus and Cecropia pachystachya, lowers blood pressure in vivo in rats, but toxicity is low — no lethality was shown with up to four to six times the effective dose of 100 mg/kg of methanol (!) extract. #toxicology
on 02015-11-22MSDSOnline is a disinformation site, as evidenced by this page that recommends wearing gloves to handle sodium chloride and treating ingestion as follows: “If person is conscious, rinse mouth with plenty of water and give several glasses of water to drink.” #toxicology
on 02015-09-01Tetra-ethoxy silane, or "ethyl silicate" or "tetraethyl orthosilicate", forms silica upon exposure to water. You could use this to 3-D print silica directly by squirting it into water. It’s very hazardous, though, because it forms silica when the vapors get into your eyes. Apparently, in one of the most bizarre features of #toxicology, it’s safe to drink. Methyl silicate also exists but is even more dangerous because it hydrolyzes even faster.
on 02015-08-30#waterglass nonahydrate is “efflorescent sticky crystals”, while amorphous and pentahydrate are pellets. “Sodium metasilicate, International Programme on Chemical Safety, Poisons Information Monograph 500” #toxicology
on 02015-08-30Sodium Metasilicate, Anhydrous [6834-92-0], Sodium Metasilicate Pentahydrate [10213-79-3], and Sodium Metasilicate Nonahydrate [13517-24-3] Review of Toxicological Literature, January 2002 (sodium metasilicate is sodium silicate, aka #toxicology #waterglass.) Notes that you can recover the metasilicate from ordinary silica gel by adding an alkali, such as sodium hydroxide, which sounds a lot easier than the silica-sodium-carbonate reaction at 1400°. Also notes that it’s sufficiently alkaline to be corrosive to many metals.
on 02015-08-30Turns out #acrylamide is a (potential) human carcinogen, and the acute fatal dose is a few grams. However, polyacrylamide, a highly water-absorbent plastic, is so nontoxic it’s used in contact lenses and as a subdermal filler. #toxicology
on 02015-08-15